Merkle, Florian T. and Maroof, Asif and Wataya, Takafumi and Sasai, Yoshiki and Studer, Lorenz and Eggan, Kevin and Schier, Alexander F.. (2015) Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England), 142 (4). pp. 633-643.
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Official URL: https://edoc.unibas.ch/74132/
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Abstract
Hypothalamic neurons orchestrate many essential physiological and behavioral processes via secreted neuropeptides, and are relevant to human diseases such as obesity, narcolepsy and infertility. We report the differentiation of human pluripotent stem cells into many of the major types of neuropeptidergic hypothalamic neurons, including those producing pro-opiolemelanocortin, agouti-related peptide, hypocretin/orexin, melanin-concentrating hormone, oxytocin, arginine vasopressin, corticotropin-releasing hormone (CRH) or thyrotropin-releasing hormone. Hypothalamic neurons can be generated using a 'self-patterning' strategy that yields a broad array of cell types, or via a more reproducible directed differentiation approach. Stem cell-derived human hypothalamic neurons share characteristic morphological properties and gene expression patterns with their counterparts in vivo, and are able to integrate into the mouse brain. These neurons could form the basis of cellular models, chemical screens or cellular therapies to study and treat common human diseases.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier) |
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UniBasel Contributors: | Schier, Alexander |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
ISSN: | 1477-9129 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Last Modified: | 26 May 2020 15:37 |
Deposited On: | 26 May 2020 15:37 |
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