Insula Volume Reductions in Patients with Major Depressive Disorder

Mutschler, Isabella and Hänggi, Jürgen and Frei, Manuela and Lieb, Roselind and Grosse Holforth , Martin and Seifritz, Erich and Spinelli, Simona. (2019) Insula Volume Reductions in Patients with Major Depressive Disorder. Neurology, Psychiatry and Brain Reasearch, 33. pp. 39-47.

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Official URL: https://edoc.unibas.ch/73052/

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Major Depressive Disorder (MDD) is one of the most common mental disorders. Converging evidence suggests that the insula plays an important role in the pathophysiology of MDD. Little is known regarding in which insula subregion volume alterations occur in patients with MDD. We analyzed voxel-based morphometry in T1-weighted MRI scans of unmedicated DSM-IV MDD patients (n = 26) and in age, education, and sex matched healthy controls (HC, n = 26). Furthermore, we performed a quantitative meta-analysis across 14 structural MRI MDD studies by applying the anatomical likelihood estimation technique to identify concordant volume reductions in MDD in the insula cortex. We found significantly reduced grey matter volumes (GMV) in patients with MDD compared to HCs in the left mid-insula and in the right and left caudate nucleus. The left mid-insular volume reduction in our sample was consistent with the coordinate-based meta-analysis results. The findings highlight the role of the mid-insula in the psychopathology of MDD. The mid-insula subregion might be associated with reduced interoceptive abilities in patients with MDD that is the ability to process information of “how the body feels”. In addition, the caudate nucleus has been described as being part of a network that mediates emotional and motivational processes which seems to be affected in MDD.
Faculties and Departments:07 Faculty of Psychology
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Sep 2020 06:30
Deposited On:21 Sep 2020 06:30

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