Expression of CD164 on Malignant T cells in Sézary Syndrome

Guenova, Emmanuella and Ignatova, Desislava and Chang, Yun-Tsan and Contassot, Emmanuel and Mehra, Tarun and Saulite, Ieva and Navarini, Alexander A. and Mitev, Vanyo and Dummer, Reinhard and Kazakov, Dmitry V. and French, Lars E. and Hoetzenecker, Wolfram and Cozzio, Antonio. (2016) Expression of CD164 on Malignant T cells in Sézary Syndrome. Acta Dermato-Venereologica, 96 (4). pp. 464-467.

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Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by pruritic erythroderma, peripheral lymphadenopathy and the presence of malignant T cells in the blood. Unequivocal detection of malignant cells in patients with Sézary syndrome is of important diagnostic, prognostic and therapeutic value. However, no single Sézary syndrome specific cell surface marker has been identified. In a cohort of patients with Sézary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls. CD164 expression was in most cases limited to CD4+CD26- malignant T lymphocytes, unequivocally identified using flow-cytometry by the expression of a specific Vβ clone for each patient. Increased expression of CD164 may be a promising diagnostic parameter and a potential target for a CD164-linked therapeutic approach in Sézary syndrome.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 May 2020 19:38
Deposited On:21 May 2020 19:38

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