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Hybrid nanocapsules: Interactions of ABA block copolymers with liposomes

Ruysschaert, Tristan and Sonnen, Andreas F. P. and Haefele, Thomas and Meier, Wolfgang and Winterhalter, Mathias and Fournier, Didier. (2005) Hybrid nanocapsules: Interactions of ABA block copolymers with liposomes. Journal of the American Chemical Society, 127 (17). pp. 6242-6247.

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Official URL: https://edoc.unibas.ch/72411/

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Abstract

Amphiphilic ABA triblock copolymers, such as poly(2-methyloxazoline)-block-poly(dimethylsiloxan)-block-poly(2-methyloxazoline) (PMOXA-PDMS-PMOXA), form vesicular structures. Here, the interaction of these ABA molecules with lipids is investigated by electron microscopy, fluorescence spectroscopy, light scattering, and differential scanning calorimetry. Our observations suggest the formation of homogeneous mixed polymerâˆ'lipid composites, independent of preparation method, i.e. film hydration, dispersion, or detergent removal. When ABA polymersomes and liposomes are mixed, we observed monomer exchanges on a time scale of minutes. The possibility of forming mixed structures and the exchanges between preformed structures allow the combination of the properties of lipids and polymers such as stability and loading encapsulation capacity.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:0002-7863
e-ISSN:1520-5126
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Mar 2020 15:44
Deposited On:11 Mar 2020 15:44

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