Viscosity- and Inertia-Limited Rupture of Dextran-Supported Black Lipid Membranes

Diederich, Anke and Strobel, Michael and Meier, Wolfgang and Winterhalter, Mathias. (1999) Viscosity- and Inertia-Limited Rupture of Dextran-Supported Black Lipid Membranes. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry, 103 (9). pp. 1402-1407.

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We study the rupture of polymer-supported black lipid membranes (BLMs). The irreversible rupture of membranes is triggered by application of short transmembrane voltage pulses. The rapid membrane discharge during rupture permits the evaluation of the kinetics of defect widening. The linear increase of the membrane conductance in time during the rupture process indicates that the widening is determined by the inertia of the BLMs. Defects in polymer-free BLMs increase in size with about 20 cm/s. To decrease the rupture velocity of the membranes we attach high-molecular-weight dextran derivatives via hydrophobic dodecyl anchor groups to the BLMs. The density of the hydrophobic anchor groups along the polymer chains is found to be of considerable influence:âEuro‰ While dextran with a low anchor-group density slows down the inertia-driven rupture process of BLMs, dextran with higher anchor-group density alters the kinetics and causes an exponential increase of the membrane conductance, suggesting a viscosity-determined rupture process. Dextran derivatives of medium anchor-group density show a transition from a viscosity- to an inertia-limited rupture.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Mar 2020 14:50
Deposited On:19 Mar 2020 14:50

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