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Antibiotic-resistant Escherichia coli in drinking water samples from rural Andean households in Cajamarca, Peru

Larson, Anika and Hartinger, Stella Maria and Riveros, Maribel and Salmon-Mulanovich, Gabriela and Hattendorf, Jan and Verastegui, Hector and Huaylinos, Maria Luisa and Mäusezahl, Daniel. (2019) Antibiotic-resistant Escherichia coli in drinking water samples from rural Andean households in Cajamarca, Peru. American journal of tropical medicine and hygiene, 100 (6). pp. 1363-1368.

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Official URL: https://edoc.unibas.ch/71190/

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Abstract

Antibiotic resistance in pathogenic bacteria is a serious public health issue. The growing threat is a cause for concern and action to prevent the emergence of new resistant strains and the spread of existing ones to humans via the environment. This study aimed at identifying fecal pathogens in drinking water obtained from rural Andean households from Cajamarca, Peru, and measuring the antibiotic resistance profile of; Escherichia coli; . The study was embedded within a community-randomized controlled trial among 102 communities in the northern highlands of the Cajamarca region, Peru. Of 314 samples, 55.4% (95% CI [49.7, 61.0],; n; = 174) were identified as thermotolerant coliforms. Among the samples positive for thermotolerant coliform,; E. coli; was isolated in 37.3% (; n; = 117),; Klebsiella; spp; .; in 8.0% (; n; = 25),; Enterobacter; spp; .; in 5.1% (; n; = 16), and; Citrobacter; spp; .; in 2.5% (; n; = 8). Of the 117; E. coli; samples, 48.7% (95% CI [39.4, 58.1],; n; = 57) showed resistance to any antibiotic. The; E. coli; antibiotic resistance profile showed highest resistance against tetracycline (37.6%), ampicillin (34.2%), sulfamethoxazole-trimethoprim (21.4%), and nalidixic acid (13%). Some 19.7% (95% CI [12.9, 28.0],; n; = 23) of the; E. coli; isolates displayed multidrug resistance, defined as resistance to at least three classes of antibiotics. The CTX-M-3 gene, which encodes extended-spectrum resistance to beta-lactamase antibiotics, was found in one isolate. The high prevalence of fecal contamination in drinking water highlights the importance of household water treatment methods. Likewise, the high levels of antibiotic resistance found indicate a need for further research to identify the origins of potential environmental contamination, misuse, or inadequate disposal of antibiotics.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Household Economics and Health Systems Research > Household Health Systems (Mäusezahl)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
UniBasel Contributors:Hartinger, Stella and Hattendorf, Jan and Mäusezahl, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2019 13:40
Deposited On:10 Jul 2019 13:40

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