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RTS,S malaria vaccine pilot studies : addressing the human realities in large-scale clinical trials

van den Berg, Machteld and Ogutu, Bernhards and Sewankambo, Nelson K. and Biller-Andorno, Nikola and Tanner, Marcel. (2019) RTS,S malaria vaccine pilot studies : addressing the human realities in large-scale clinical trials. Trials, 20. p. 316.

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Abstract

A malaria vaccine as part of the integrated malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot implementation in three African countries. These pilot implementation studies are being initiated in Kenya, Malawi, and Ghana to inform the broader roll-out recommendation. Based on the malaria vaccine clinical trial experiences, key ethical practices for effective clinical trial research in low-resource settings are described. For successful vaccine integration into malaria intervention programs, the relational dynamics between researchers and trial communities must be made explicit. Incorporating community values and returning to research practices that serve the intended benefactors are key strategies that address the human realities in large-scale clinical trials and pilot implementation, leading to positive public health outcomes.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
UniBasel Contributors:Tanner, Marcel and van den Berg, Machteld
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:BioMed Central
ISSN:1468-6708
e-ISSN:1745-6215
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
Identification Number:
Last Modified:10 Jul 2019 13:29
Deposited On:10 Jul 2019 13:29

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