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Mycobacterium tuberculosis lineage 1 genetic diversity in Pará, Brazil, suggests common ancestry with east-African isolates potentially linked to historical slave trade

Conceição, Emilyn Costa and Refregier, Guislaine and Gomes, Harrison Magdinier and Olessa-Daragon, Xavier and Coll, Francesc and Ratovonirina, Noël Harijaona and Rasolofo-Razanamparany, Voahangy and Lopes, Maria Luiza and van Soolingen, Dick and Rutaihwa, Liliana and Gagneux, Sebastien and Bollela, Valdes Roberto and Suffys, Philip Noel and Duarte, Rafael Silva and Lima, Karla Valéria Batista and Sola, Christophe Noel. (2019) Mycobacterium tuberculosis lineage 1 genetic diversity in Pará, Brazil, suggests common ancestry with east-African isolates potentially linked to historical slave trade. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 73. pp. 337-341.

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Official URL: https://edoc.unibas.ch/70922/

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Abstract

Lineage 1 (L1) is one of seven Mycobacterium tuberculosis complex (MTBC) lineages. The objective of this study was to improve the complex taxonomy of L1 using phylogenetic SNPs, and to look for the origin of the main L1 sublineage prevalent in Para, Brazil. We developed a high-throughput SNPs-typing assay based on 12-L1-specific SNPs. This assay allowed us to experimentally retrieve SNP patterns on nine of these twelve SNPs in 277 isolates previously tentatively assigned to L1 spoligotyping-based sub lineages. Three collections were used: Pará-Brazil (71); RIVM, the Netherlands (102), Madagascar (104). One-hundred more results were generated in Silico using the PolyTB database. Based on the final SNPs combination, the samples were classified into 11 clusters (C1-C11). Most isolates within a SNP-based cluster shared a mutual spoligotyping-defined lineage. However, L1/EAI1-SOM (SIT48, sp. 40) and L1/EAI6-BGD1 (SIT591, sp. 23) showed a poor correlation with SNP data and are not monophyletic. L1/EAI8-MDG and L1/EAI3-IND belonged to C5; this result suggests that they share a common ancestor. L1.1.3/SIT129, a spoligotype pattern found in SNPs-cluster C6, was found to be shared between Pará/Brazil and Malawi. SIT129 was independently found to be highly prevalent in Mozambique, which suggests a migration history from East-Africa to Brazil during the 16th-18th slave trade period to Northern Brazil.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Rutaihwa, Liliana and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1567-7257
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2019 12:45
Deposited On:10 Jul 2019 12:45

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