Mastocytosis: a disease of the hematopoietic stem cell

Horny, Hans-Peter and Sotlar, Karl and Valent, Peter and Hartmann, Karin. (2008) Mastocytosis: a disease of the hematopoietic stem cell. Deutsches Ärzteblatt International, 105 (40). pp. 686-692.

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Official URL: https://edoc.unibas.ch/70883/

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Mastocytosis is an unusual clonal disease of the hematopoietic stem cell.; This article is based on a selective literature search and on the authors' clinical and pathological experience.; The clinical manifestations of mastocytosis range from cutaneous mastocytosis, a common, prognostically favorable presentation, to mast cell leukemia, a rare, life-threatening disease. The mediator-induced symptoms usually respond well to H1 antihistamines. Therapeutic standards for cytoreduction in the progressive, systemic forms of mastocytosis are still lacking.; Because some of the manifestations of mastocytosis are nonspecific and can be mimicked by other diseases, there is a risk of two types of diagnostic error: Mastocytosis may remain undiagnosed when it is actually present, or it may be diagnosed even though morphological and molecular findings rule out mastocytosis. Well-defined criteria should be used to differentiate mastocytosis from other diseases with a similar clinical presentation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 12:51
Deposited On:10 Nov 2020 12:51

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