AllergoOncology: microbiota in allergy and cancer - a European Academy for Allergy and Clinical Immunology position paper

Untersmayr, Eva and Bax, Heather J. and Bergmann, Christoph and Bianchini, Rodolfo and Cozen, Wendy and Gould, Hannah J. and Hartmann, Karin and Josephs, Debra H. and Levi-Schaffer, Francesca and Penichet, Manuel L. and O'Mahony, Liam and Poli, Aurelie and Redegeld, Frank A. and Roth-Walter, Franziska and Turner, Michelle C. and Vangelista, Luca and Karagiannis, Sophia N. and Jensen-Jarolim, Erika. (2019) AllergoOncology: microbiota in allergy and cancer - a European Academy for Allergy and Clinical Immunology position paper. Allergy, 74 (6). pp. 1037-1051.

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Official URL: https://edoc.unibas.ch/70716/

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The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 16:33
Deposited On:10 Nov 2020 16:33

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