Jenkins, Noah and Saam, Jennifer R. and Mango, Susan E.. (2006) CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization. Science, 313 (5791). pp. 1298-1301.
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Official URL: https://edoc.unibas.ch/70585/
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Abstract
The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity. These data suggest that CYK-4 provides a molecular link between fertilization and polarity establishment in the one-cell embryo. Orthologs of CYK-4 are expressed in sperm of other species, which suggests that this cue may be evolutionarily conserved.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango) |
|---|---|
| UniBasel Contributors: | Mango, Susan Elizabeth |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| e-ISSN: | 1095-9203 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 13 Nov 2020 10:03 |
| Deposited On: | 13 Nov 2020 10:03 |
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