Alder, Matthew N. and Dames, Shale and Gaudet, Jeffrey and Mango, Susan E.. (2003) Gene silencing in Caenorhabditis elegans by transitive RNA interference. RNA, 9 (1). pp. 25-32.
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Official URL: https://edoc.unibas.ch/70576/
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Abstract
When a cell is exposed to double-stranded RNA (dsRNA), mRNA from the homologous gene is selectively degraded by a process called RNA interference (RNAi). Here, we provide evidence that dsRNA is amplified in Caenorhabditis elegans to ensure a robust RNAi response. Our data suggest a model in which mRNA targeted by RNAi functions as a template for 5' to 3' synthesis of new dsRNA (termed transitive RNAi). Strikingly, the effect is nonautonomous: dsRNA targeted to a gene expressed in one cell type can lead to transitive RNAi-mediated silencing of a second gene expressed in a distinct cell type. These data suggest dsRNA synthesized in vivo can mediate systemic RNAi.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango) |
|---|---|
| UniBasel Contributors: | Mango, Susan Elizabeth |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Cambridge University Press |
| ISSN: | 1355-8382 |
| e-ISSN: | 1469-9001 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 13 Nov 2020 09:23 |
| Deposited On: | 13 Nov 2020 09:23 |
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