Gene silencing in Caenorhabditis elegans by transitive RNA interference

Alder, Matthew N. and Dames, Shale and Gaudet, Jeffrey and Mango, Susan E.. (2003) Gene silencing in Caenorhabditis elegans by transitive RNA interference. RNA, 9 (1). pp. 25-32.

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Official URL: https://edoc.unibas.ch/70576/

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When a cell is exposed to double-stranded RNA (dsRNA), mRNA from the homologous gene is selectively degraded by a process called RNA interference (RNAi). Here, we provide evidence that dsRNA is amplified in Caenorhabditis elegans to ensure a robust RNAi response. Our data suggest a model in which mRNA targeted by RNAi functions as a template for 5' to 3' synthesis of new dsRNA (termed transitive RNAi). Strikingly, the effect is nonautonomous: dsRNA targeted to a gene expressed in one cell type can lead to transitive RNAi-mediated silencing of a second gene expressed in a distinct cell type. These data suggest dsRNA synthesized in vivo can mediate systemic RNAi.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cambridge University Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Nov 2020 09:23
Deposited On:13 Nov 2020 09:23

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