Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Helmy, Remon and de Almeida, Samira Scalso and Denhaerynck, Kris and Berben, Lut and Dobbels, Fabienne and Russell, Cynthia L. and Roza, Bartira de Aguiar and De Geest, Sabina and Crespo-Leiro, Marisa G. and Guppies, Sandra and De Simone, Paolo and Groenewoud, Albert and Kugler, Christiane and Ohler, Linda and Van Cleemput, Johan and Poncelet, Alain Jean and Sebbag, Laurent and Michel, Magali and Bernard, Andree and Doesch, Andreas and Livi, Ugolino and Potena, Luciano and Brossa-Loidi, Vicens and Segovia-Cubero, Javier and Almenar-Bonet, Luis and Segura Saint-Gerons, Carmen and Mohacsi, Paul and Horvath, Eva and Riotto, Cheryl and Parry, Gareth and Firouzi, Ashi and Kozuszko, Stella and Haddad, Haissam and Kaan, Annemarie and Fisher, Grant and Miller, Tara and Flattery, Maureen and Ludrosky, Kristin and Albert, Nancy and Coleman, Bernice and Trammell, Jacqueline and Epstein, Flavio and St Clair, Katherine and Kao, Andrew and Molina, Maria and Canales, Karyn Ryan and de Almeida, Samira Scalso and Ayoub, Andrea Cotait and Barone, Fernanda and Harkess, Michelle and Maddicks-Law, Joanne and Bright Study Team, . (2019) Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study. Clinical therapeutics, 41 (1). pp. 130-136.

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Official URL: https://edoc.unibas.ch/70475/

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Abstract

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients.Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries.Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

Faculties and Departments:	03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft 03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft > Pflegewissenschaft (De Geest)
UniBasel Contributors:	Denhaerynck, Kris and De Geest, Sabina M. and Berben, Lut
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Excerpta Medica
ISSN:	0149-2918
e-ISSN:	1879-114X
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1016/j.clinthera.2018.11.007 isi: 000457649700015
Last Modified:	06 Jul 2022 13:40
Deposited On:	02 Jul 2020 16:14

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