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Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project

Huerta, Consuelo and Abbing-Karahagopian, Victoria and Requena, Gema and Oliva, Belén and Alvarez, Yolanda and Gardarsdottir, Helga and Miret, Montserrat and Schneider, Cornelia and Gil, Miguel and Souverein, Patrick C. and De Bruin, Marie L. and Slattery, Jim and De Groot, Mark C. H. and Hesse, Ulrik and Rottenkolber, Marietta and Schmiedl, Sven and Montero, Dolores and Bate, Andrew and Ruigomez, Ana and García-Rodríguez, Luis Alberto and Johansson, Saga and de Vries, Frank and Schlienger, Raymond G. and Reynolds, Robert F. and Klungel, Olaf H. and de Abajo, Francisco José. (2016) Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project. Pharmacoepidemiology and drug safety, 25 Suppl 1. pp. 56-65.

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Official URL: https://edoc.unibas.ch/70459/

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Abstract

Studies on drug utilization usually do not allow direct cross-national comparisons because of differences in the respective applied methods. This study aimed to compare time trends in BZDs prescribing by applying a common protocol and analyses plan in seven European electronic healthcare databases.; Crude and standardized prevalence rates of drug prescribing from 2001-2009 were calculated in databases from Spain, United Kingdon (UK), The Netherlands, Germany and Denmark. Prevalence was stratified by age, sex, BZD type [(using ATC codes), i.e. BZD-anxiolytics BZD-hypnotics, BZD-related drugs and clomethiazole], indication and number of prescription.; Crude prevalence rates of BZDs prescribing ranged from 570 to 1700 per 10,000 person-years over the study period. Standardization by age and sex did not substantially change the differences. Standardized prevalence rates increased in the Spanish (+13%) and UK databases (+2% and +8%) over the study period, while they decreased in the Dutch databases (-4% and -22%), the German (-12%) and Danish (-26%) database. Prevalence of anxiolytics outweighed that of hypnotics in the Spanish, Dutch and Bavarian databases, but the reverse was shown in the UK and Danish databases. Prevalence rates consistently increased with age and were two-fold higher in women than in men in all databases. A median of 18% of users received 10 or more prescriptions in 2008.; Although similar methods were applied, the prevalence of BZD prescribing varied considerably across different populations. Clinical factors related to BZDs and characteristics of the databases may explain these differences.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Spital-Pharmazie > Spitalpharmazie (Meier)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Spital-Pharmazie > Spitalpharmazie (Meier)
UniBasel Contributors:Schneider, Cornelia
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1099-1557
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 May 2020 20:36
Deposited On:17 May 2020 20:36

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