Anti-inflammatory and quinone reductase-inducing compounds from Beilschmiedia mannii

Ahoua, Angora Rémi Constant and Monteillier, Aymeric and Borlat, Frédéric and Ciclet, Olivier and Marcourt, Laurence and Nejad Ebrahimi, Samad and Koné, Mamidou Witabouna and Bonfoh, Bassirou and Christen, Philippe and Cuendet, Muriel. (2019) Anti-inflammatory and quinone reductase-inducing compounds from Beilschmiedia mannii. Planta medica, 85 (5). pp. 379-384.

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Official URL: https://edoc.unibas.ch/70260/

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Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in Taï National Park have shown that they could be potential candidates for the search of new molecules useful for humans. Based on the screening of some of these plants, the fruits of; Beilschmiedia mannii; , whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two; γ; -pyrones, including desmethoxydihydromethysticin (1: ), found in a natural source for the first time, and a new congener, beilschmiediapyrone (2: ), as well as five known alkamides (3: - 7: ). Their structures were established by using nuclear magnetic resonance spectroscopy and mass spectrometry methods. The isolated compounds were evaluated for their cancer chemopreventive potential by using quinone reductase induction and nuclear factor-kappa B inhibition tests in Hepa 1c1c7 and HEK-293/NF-; κ; B-Luc cells, respectively. Among them, compounds 1: and 2: were the most active. The concentrations to double the quinone reductase activity were 7.5 µM for compound 1: and 6.1 µM for compound 2: . Compounds 1: and 2: inhibited nuclear factor-kappa B with IC; 50; values of 2.1 and 3.4 µM, respectively. These results are promising with regard to cancer chemoprevention, especially because this plant is also used for cooking by the local population around the Taï forest.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Bonfoh, Bassirou
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Apr 2019 09:31
Deposited On:23 Apr 2019 09:31

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