Hevey, Rachel and Ling, Chang-Chun. (2012) Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies. Future Medicinal Chemistry, 4 (4). pp. 545-584.
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Official URL: https://edoc.unibas.ch/70097/
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Abstract
Cancer cells can often be distinguished from healthy cells by the expression of unique carbohydrate sequences decorating the cell surface as a result of aberrant glycosyltransferase activity occurring within the cell; these unusual carbohydrates can be used as valuable immunological targets in modern vaccine designs to raise carbohydrate-specific antibodies. Many tumor antigens (e.g., GM2, Le(y), globo H, sialyl Tn and TF) have been identified to date in a variety of cancers. Unfortunately, carbohydrates alone evoke poor immunogenicity, owing to their lack of ability in inducing T-cell-dependent immune responses. In order to enhance their immunogenicity and promote long-lasting immune responses, carbohydrates are often chemically modified to link to an immunogenic protein or peptide fragment for eliciting T-cell-dependent responses. This review will present a summary of efforts and advancements made to date on creating carbohydrate-based anticancer vaccines, and will include novel approaches to overcoming the poor immunogenicity of carbohydrate-based vaccines.
Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Molekulare Pharmazie (Ernst) 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular Pharmacy (Ricklin) |
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UniBasel Contributors: | Hevey, Rachel |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Newlands Press |
ISSN: | 1756-8919 |
e-ISSN: | 1756-8927 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Identification Number: |
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Last Modified: | 16 Nov 2020 10:18 |
Deposited On: | 16 Nov 2020 10:18 |
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