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DNA Methylation Patterns in the Round Goby Hypothalamus Support an On-The-Spot Decision Scenario for Territorial Behavior

Somerville, Vincent and Schwaiger, Michaela and Hirsch, Philipp E. and Walser, Jean-Claude and Bussmann, Karen and Weyrich, Alexandra and Burkhardt-Holm, Patricia and Adrian-Kalchhauser, Irene. (2019) DNA Methylation Patterns in the Round Goby Hypothalamus Support an On-The-Spot Decision Scenario for Territorial Behavior. Genes, 10 (3). p. 219.

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Official URL: https://edoc.unibas.ch/69894/

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Abstract

The question as to how early life experiences are stored on a molecular level and affect traits later in life is highly topical in ecology, medicine, and epigenetics. In this study, we use a fish model to investigate whether DNA methylation mediates early life experiences and predetermines a territorial male reproductive phenotype. In fish, adult reproductive phenotypes frequently depend on previous life experiences and are often associated with distinct morphological traits. DNA methylation is an epigenetic mechanism which is both sensitive to environmental conditions and stably inherited across cell divisions. We therefore investigate early life predisposition in the round goby Neogobius melanostomus by growth back-calculations and then study DNA methylation by MBD-Seq in the brain region controlling vertebrate reproductive behavior, the hypothalamus. We find a link between the territorial reproductive phenotype and high growth rates in the first year of life. However, hypothalamic DNA methylation patterns reflect the current behavioral status independently of early life experiences. Together, our data suggest a non-predetermination scenario in the round goby, in which indeterminate males progress to a non-territorial status in the spawning season, and in which some males then assume a specialized territorial phenotype if current conditions are favorable.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften
05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Aquatische ├ľkologie (Holm)
UniBasel Contributors:Adrian-Kalchhauser, Irene and Holm, Patricia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Multidisciplinary Digital Publishing Institute
ISSN:2073-4425
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Jul 2020 09:03
Deposited On:27 Apr 2020 16:35

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