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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Shrine, Nick and Guyatt, Anna L. and Erzurumluoglu, A. Mesut and Jackson, Victoria E. and Hobbs, Brian D. and Melbourne, Carl A. and Batini, Chiara and Fawcett, Katherine A. and Song, Kijoung and Sakornsakolpat, Phuwanat and Li, Xingnan and Boxall, Ruth and Reeve, Nicola F. and Obeidat, Ma'en and Zhao, Jing Hua and Wielscher, Matthias and Understanding Society Scientific Group, and Weiss, Stefan and Kentistou, Katherine A. and Cook, James P. and Sun, Benjamin B. and Zhou, Jian and Hui, Jennie and Karrasch, Stefan and Imboden, Medea and Harris, Sarah E. and Marten, Jonathan and Enroth, Stefan and Kerr, Shona M. and Surakka, Ida and Vitart, Veronique and Lehtimäki, Terho and Allen, Richard J. and Bakke, Per S. and Beaty, Terri H. and Bleecker, Eugene R. and Bossé, Yohan and Brandsma, Corry-Anke and Chen, Zhengming and Crapo, James D. and Danesh, John and DeMeo, Dawn L. and Dudbridge, Frank and Ewert, Ralf and Gieger, Christian and Gulsvik, Amund and Hansell, Anna L. and Hao, Ke and Hoffman, Joshua D. and Hokanson, John E. and Homuth, Georg and Joshi, Peter K. and Joubert, Philippe and Langenberg, Claudia and Li, Xuan and Li, Liming and Lin, Kuang and Lind, Lars and Locantore, Nicholas and Luan, Jian'an and Mahajan, Anubha and Maranville, Joseph C. and Murray, Alison and Nickle, David C. and Packer, Richard and Parker, Margaret M. and Paynton, Megan L. and Porteous, David J. and Prokopenko, Dmitry and Qiao, Dandi and Rawal, Rajesh and Runz, Heiko and Sayers, Ian and Sin, Don D. and Smith, Blair H. and Soler Artigas, María and Sparrow, David and Tal-Singer, Ruth and Timmers, Paul R. H. J. and Van den Berge, Maarten and Whittaker, John C. and Woodruff, Prescott G. and Yerges-Armstrong, Laura M. and Troyanskaya, Olga G. and Raitakari, Olli T. and Kähönen, Mika and Polašek, Ozren and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J. and Probst-Hensch, Nicole M. and Schulz, Holger and James, Alan L. and Wilson, James F. and Stubbe, Beate and Zeggini, Eleftheria and Jarvelin, Marjo-Riitta and Wareham, Nick and Silverman, Edwin K. and Hayward, Caroline and Morris, Andrew P. and Butterworth, Adam S. and Scott, Robert A. and Walters, Robin G. and Meyers, Deborah A. and Cho, Michael H. and Strachan, David P. and Hall, Ian P. and Tobin, Martin D. and Wain, Louise V.. (2019) New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature genetics, 51 (3). pp. 481-493.

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Official URL: https://edoc.unibas.ch/69742/

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Abstract

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Imboden, Medea and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publ
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Mar 2019 12:53
Deposited On:12 Mar 2019 12:53

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