edoc

Nanoscience-Based Strategies to Engineer Antimicrobial Surfaces

Rigo, Serena and Cai, Chao and Gunkel-Grabole, Gesine and Maurizi, Lionel and Zhang, Xiaoyan and Xu, Jian and Palivan, Cornelia G.. (2018) Nanoscience-Based Strategies to Engineer Antimicrobial Surfaces. Advanced Science, 5 (5). p. 1700892.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/69311/

Downloads: Statistics Overview

Abstract

Microbial contamination and biofilm formation of medical devices is a major issue associated with medical complications and increased costs. Consequently, there is a growing need for novel strategies and exploitation of nanoscience-based technologies to reduce the interaction of bacteria and microbes with synthetic surfaces. This article focuses on surfaces that are nanostructured, have functional coatings, and generate or release antimicrobial compounds, including ``smart surfaces`` producing antibiotics on demand. Key requirements for successful antimicrobial surfaces including biocompatibility, mechanical stability, durability, and efficiency are discussed and illustrated with examples of the recent literature. Various nanoscience-based technologies are described along with new concepts, their advantages, and remaining open questions. Although at an early stage of research, nanoscience-based strategies for creating antimicrobial surfaces have the advantage of acting at the molecular level, potentially making them more efficient under specific conditions. Moreover, the interface can be fine tuned and specific interactions that depend on the location of the device can be addressed. Finally, remaining important challenges are identified: improvement of the efficacy for long-term use, extension of the application range to a large spectrum of bacteria, standardized evaluation assays, and combination of passive and active approaches in a single surface to produce multifunctional surfaces.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2198-3844
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Aug 2019 13:14
Deposited On:27 Aug 2019 13:14

Repository Staff Only: item control page