edoc

Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases

Jeong, Ayoung and Fiorito, Giovanni and Keski-Rahkonen, Pekka and Imboden, Medea and Kiss, Agneta and Robinot, Nivonirina and Gmuender, Hans and Vlaanderen, Jelle and Vermeulen, Roel and Kyrtopoulos, Soterios and Herceg, Zdenko and Ghantous, Akram and Lovison, Gianfranco and Galassi, Claudia and Ranzi, Andrea and Krogh, Vittorio and Grioni, Sara and Agnoli, Claudia and Sacerdote, Carlotta and Mostafavi, Nahid and Naccarati, Alessio and Scalbert, Augustin and Vineis, Paolo and Probst-Hensch, Nicole and ExposOmics Consortium, . (2018) Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases. Environment international, 119. pp. 334-345.

[img] PDF - Published Version
Available under License CC BY (Attribution).

1295Kb

Official URL: https://edoc.unibas.ch/69244/

Downloads: Statistics Overview

Abstract

Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways.; The goal was to find intermediate metabolites or metabolic pathways that could be associated with both air pollutants and health outcomes ("meeting-in-the-middle"), thus shedding light on mechanisms and reinforcing causality.; We applied a statistical approach named 'meet-in-the-middle' to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases (CCVD). We compared the results to identify both common and disease-specific altered metabolic pathways.; A novel finding was a strong association of AOA with ultrafine particles (UFP; odds ratio 1.80 [1.26, 2.55] per increase by 5000 particles/cm; 3; ). Further, we have identified several metabolic pathways that potentially mediate the effect of air pollution on health outcomes. Among those, perturbation of Linoleate metabolism pathway was associated with air pollution exposure, AOA and CCVD.; Our results suggest common pathway perturbations may occur as a consequence of chronic exposure to air pollution leading to increased risk for both AOA and CCVD.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Jeong, Ayoung and Imboden, Medea and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0160-4120
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:01 Mar 2019 14:29
Deposited On:01 Mar 2019 14:29

Repository Staff Only: item control page