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Recovery and Recycling of Chiral Iridium(N,P Ligand) Catalysts from Hydrogenation Reactions

Müller, Marc-André and Gruber, Stefan and Pfaltz, Andreas. (2018) Recovery and Recycling of Chiral Iridium(N,P Ligand) Catalysts from Hydrogenation Reactions. Advanced synthesis & catalysis, 360 (7). pp. 1340-1345.

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Official URL: https://edoc.unibas.ch/68807/

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Abstract

Despite the high efficiency and broad scope of chiral iridium(N,P ligand) complexes as catalysts for asymmetric hydrogenation, the problem of catalyst recovery and recycling has so far attracted little attention. We have found that at the end of a hydrogenation reaction, iridium(N,P ligand) catalysts form dimeric Ir(III) dihydride complexes, which can be converted back to the original precatalysts by addition of COD. Based on these findings, a practically simple protocol for catalyst recovery was devised. The recovered complexes showed essentially the same reactivity and enantioselectivity as the original catalysts. Especially large-scale applications and hydrogenations of less reactive substrates that require high catalyst loadings will benefit from this protocol that allows recovery and reuse of expensive iridium complexes.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1615-4150
e-ISSN:1615-4169
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:20 Feb 2019 08:47
Deposited On:20 Feb 2019 08:47

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