Zhao, Jingming and Bachmann, Daniel G. and Lenz, Markus and Gillingham, Dennis G. and Ward, Thomas R.. (2018) An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin. Catalysis science & technology, 8 (9). pp. 2294-2298.
![[img]](https://edoc.unibas.ch/style/images/fileicons/application_pdf.png)
|
PDF
- Accepted Version
2003Kb |
Official URL: https://edoc.unibas.ch/68780/
Downloads: Statistics Overview
Abstract
We report on artificial metalloenzymes that incorporate a biotinylated dirhodium core embedded within engineered streptavidin (Sav hereafter) variants. The resulting biohybrid catalyzes the carbene insertion in C-H bonds and olefins. Chemical- and genetic optimization allows to modulate the catalytic activity of the artificial metalloenzymes that are shown to be active in the periplasm of E. coli (up to 20 turnovers).
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. and Zhao, Jingming and Gillingham, Dennis and Bachmann, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2044-4753 |
| e-ISSN: | 2044-4761 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
|
| edoc DOI: | |
| Last Modified: | 04 Jul 2019 13:08 |
| Deposited On: | 18 Feb 2019 16:33 |
Repository Staff Only: item control page