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An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin

Zhao, Jingming and Bachmann, Daniel G. and Lenz, Markus and Gillingham, Dennis G. and Ward, Thomas R.. (2018) An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin. Catalysis science & technology, 8 (9). pp. 2294-2298.

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Official URL: https://edoc.unibas.ch/68780/

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Abstract

We report on artificial metalloenzymes that incorporate a biotinylated dirhodium core embedded within engineered streptavidin (Sav hereafter) variants. The resulting biohybrid catalyzes the carbene insertion in C-H bonds and olefins. Chemical- and genetic optimization allows to modulate the catalytic activity of the artificial metalloenzymes that are shown to be active in the periplasm of E. coli (up to 20 turnovers).
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Zhao, Jingming and Gillingham, Dennis and Bachmann, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:2044-4753
e-ISSN:2044-4761
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:04 Jul 2019 13:08
Deposited On:18 Feb 2019 16:33

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