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Catalyst-Controlled Stereoselective Synthesis of Atropisomers (Perspective)

Zilate, Bouthayna and Castrogiovanni, Alessandro and Sparr, Christof. (2018) Catalyst-Controlled Stereoselective Synthesis of Atropisomers (Perspective). ACS Catalysis, 8 (4). pp. 2981-2988.

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Official URL: https://edoc.unibas.ch/68649/

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Abstract

Owing to their favorable molecular topology, atropisomers represent particularly valuable chiral scaffolds for numerous applications throughout academic research and industry. Nevertheless, whereas various well-established catalyst-controlled methodologies allow addressing stereocenter configuration, efficient procedures to prepare axially chiral compounds in high isomeric purity are still scarce. Complementary to the comprehensive reviews in the area, this Perspective features representative advances for the catalyst-stereocontrolled synthesis of atropisomeric scaffolds. With a focus on axially chiral motifs frequently utilized in catalysis or medicinal chemistry, selected recent examples encompassing unique stereoselective transition metal, hydrogen bond, ion pairing, chiral phosphoric acid, and amine catalysis are highlighted.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Sparr)
UniBasel Contributors:Sparr, Christof and Zilate, Bouthayna and Castrogiovanni, Alessandro
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
e-ISSN:2155-5435
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:22 Aug 2019 12:52
Deposited On:22 Aug 2019 12:52

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