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Metal hypersensitivity in patients with orthopaedic implant complications-A retrospective clinical study

Furrer, Stefan and Scherer Hofmeier, Kathrin and Grize, Leticia and Bircher, Andreas J.. (2018) Metal hypersensitivity in patients with orthopaedic implant complications-A retrospective clinical study. Contact dermatitis, 79 (2). pp. 91-98.

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Official URL: https://edoc.unibas.ch/68173/

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Abstract

Hypersensitivity to metals as a cause of implant-related complications has been a subject of controversy. Projections indicate an increase in the frequency of joint replacements of between 300% and 600% by the year 2030; therefore, this issue is of considerable interest.; To evaluate sensitization to implant materials in patients with implant-related complications, to identify allergens, and to clarify whether hypersensitivity is a relevant cause.; Patients with implant-related complications or a positive history of contact allergy and planned total joint replacements referred for allergological investigation between 2004 and 2017 were retrospectively analysed.; In total, 311 patients were included. A positive patch test reaction to a metal was seen in 64.4% of preoperative patients and in 54.6% of patients with implant-related complications. Common alloy metals such as cobalt, chromium and titanium gave positive reactions in up to 2.9% of patients with implant-related complications. None of the patients with skin changes had a positive patch test reaction to an implant metal.; Other factors, such as the type of replaced joint and mechanical stress, seem to be more relevant for implant-related complications. Sensitization to metals or other materials seems to rarely play a role, and is overestimated.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling
UniBasel Contributors:Grize, Leticia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Blackwell
ISSN:0105-1873
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Jan 2019 10:36
Deposited On:29 Jan 2019 10:36

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