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Effects of Cannabis Use on Human Brain Structure in Psychosis: A systematic review combining in vivo structural neuroimaging and post-mortem studies

Rapp, Charlotte and Bugra, Hilal and Riecher-Rössler, Anita and Tamagni, Corinne and Borgwardt, Stefan. (2012) Effects of Cannabis Use on Human Brain Structure in Psychosis: A systematic review combining in vivo structural neuroimaging and post-mortem studies. Current Pharmaceutical Design, 18 (32). pp. 5070-5080.

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Abstract

It is unclear yet whether cannabis use is a moderating or causal factor contributing to grey matter alterations in schizophrenia and the development of psychotic symptoms. We therefore systematically reviewed structural brain imaging and post mortem studies addressing the effects of cannabis use on brain structure in psychosis. Studies with schizophrenia (SCZ) and first episode psychosis (FEP) patients as well as individuals at genetic (GHR) or clinical high risk for psychosis (ARMS) were included. We identified 15 structural magnetic resonance imaging (MRI) (12 cross sectional / 3 longitudinal) and 4 post mortem studies. The total number of subjects encompassed 601 schizophrenia or first episode psychosis patients, 255 individuals at clinical or genetic high risk for psychosis and 397 healthy controls. We found evidence for consistent brain structural abnormalities in cannabinoid 1 (CB1) receptor enhanced brain areas as the cingulate and prefrontal cortices and the cerebellum. As these effects have not consistently been reported in studies examining non-psychotic and healthy samples, psychosis patients and subjects at risk for psychosis might be particularly vulnerable to brain volume loss due to cannabis exposure.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Publishers
ISSN:1381-6128
e-ISSN:1873-4286
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:21 Aug 2019 06:34
Deposited On:23 Jan 2019 09:23

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