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Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by alpha-adrenergic mechanisms

von Kanel, Roland and Heimgartner, Nadja and Stutz, Monika and Zuccarella-Hackl, Claudia and Hansel, Alexander and Ehlert, Ulrike and Wirtz, Petra H.. (2018) Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by alpha-adrenergic mechanisms. Psychoneuroendocrinology. pp. 1-7.

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Official URL: https://edoc.unibas.ch/66981/

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Abstract

BACKGROUND: Stress-induced prothrombotic changes are mediated by the sympathetic nervous system and critically involved in mental triggering of acute coronary syndromes, but the underlying psychobiology is not fully understood. We tested the hypothesis that a norepinephrine (NE) infusion to mimic effects of stress-induced NE release on blood coagulation elicits prothrombotic changes and examined to what extent these would be mediated by an alpha-adrenergic mechanism.METHODS AND RESULTS: In a single-blind placebo-controlled within-subjects design, 24 middle-aged, non-smoking, non-obese and normotensive men participated in three experimental trials with an interval between one and two weeks. Each trial applied two sequential infusions of 1 and 15min duration with varying substances [i.e., saline as placebo, the non-specific alpha-blocker phentolamine (2.5mg/min), and NE (5mug/min)]: trial 1=saline+saline; trial 2=saline+NE, and trial 3=phentolamine+NE. Plasma levels of clotting factor VIII activity (FVIII:C), fibrinogen, and D-dimer were assessed from blood samples collected immediately before and 1min and 20min after infusion procedures. Compared to saline+saline, saline+NE induced increases over time in FVIII:C, fibrinogen, and D-dimer levels. With phentolamine+NE, fibrinogen levels remained increased compared to saline+saline, but changes in FVIII:C and D-dimer levels were no more different. Coagulation changes did not differ between saline+NE and phentolamine+NE.CONCLUSIONS: NE infusion activates blood coagulation. The resulting prothrombotic state could be one psychobiological mechanism underlying mental triggering of acute coronary syndromes. Blockade of alpha-adrenergic receptors partly attenuated NE effects on coagulation and could be implied to have preventive potential in susceptible individuals.Copyright © 2018 Elsevier Ltd. All rights reserved.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Clinical Child and Adolescent Psychology
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Heimgartner, Nadja
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0306-4530
e-ISSN:1873-3360
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Nov 2018 15:53
Deposited On:29 Nov 2018 15:53

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