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Identification of Two Distinct Working Memory-Related Brain Networks in Healthy Young Adults

Egli, Tobias and Coynel, David and Spalek, Klara and Fastenrath, Matthias and Freytag, Virginie and Heck, Angela and Loos, Eva and Auschra, Bianca and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F. and Milnik, Annette. (2018) Identification of Two Distinct Working Memory-Related Brain Networks in Healthy Young Adults. eNeuro, 5 (1). e0222-17.2018.

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Abstract

Working memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults (; N; = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance. A parietally-centered network was particularly relevant for individual differences in task measures related to WM performance ("WM dependent") and a frontally-centered network was relevant for differences in attention-dependent task performance. Importantly, frontal areas that are typically considered as key regions for WM were either involved in both WM-dependent and attention-dependent performance, or in attention-dependent performance only. The networks identified here are provided as publicly available datasets. These networks can be applied in future studies to derive a low-dimensional representation of the overall WM brain activation.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Coynel, David and Egli, Tobias and Spalek, Klara and Fastenrath, Matthias and Freytag, Virginie and Heck, Angela and Loos, Eva and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F. and Milnik, Annette
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Society for Neuroscience
ISSN:2373-2822
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:29 Nov 2018 16:31
Deposited On:29 Nov 2018 16:31

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