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Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study

Gobbi, Federico and Bottieau, Emmanuel and Bouchaud, Olivier and Buonfrate, Dora and Salvador, Fernando and Rojo-Marcos, Gerardo and Rodari, Paola and Clerinx, Jan and Treviño, Begoña and Herrera-Ávila, Juan Paulo and Neumayr, Andreas and Calleri, Guido and Angheben, Andrea and Rothe, Camilla and Zammarchi, Lorenzo and Guerriero, Massimo and Bisoffi, Zeno. (2018) Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study. PLoS Neglected Tropical Diseases, 12 (11). e0006917.

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Official URL: https://edoc.unibas.ch/66693/

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Abstract

Loa loa infection is endemic in limited areas of West-Central Africa. Loiasis has been associated with excess mortality, but clinical studies on its treatment are scant, particularly outside endemic areas, due to the rarity of cases diagnosed.; With this retrospective TropNet (European Network for Tropical Medicine and Travel Health) study, we aimed at outlining the treatment schedules followed by different reference centers for tropical medicine across Europe. We gathered information about 238 cases of loiasis, 165 of which had follow up data. The regimens followed by the different centers were heterogeneous. The drugs most frequently administered were: diethylcarbamazine alone (74/165, 45.1%), ivermectin alone (41/165, 25%), albendazole + ivermectin (21/164, 11.6%), ivermectin + diethylcarbamazine (16/165, 9.7%).; The management of loiasis substantially differs across specialized travel clinics in Europe. These discrepancies could be due to different local protocols as well as to (un)availability of the drugs. An harmonization of clinical protocols for the treatment of loiasis would be suggested across reference centers for tropical medicine in Europe.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI)
UniBasel Contributors:Neumayr, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
ISSN:1935-2727
e-ISSN:1935-2735
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:22 Nov 2018 12:26
Deposited On:22 Nov 2018 12:26

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