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Acting beyond 2020 : better characterization of praziquantel and promising antischistosomal leads

Panic, Gordana and Keiser, Jennifer. (2018) Acting beyond 2020 : better characterization of praziquantel and promising antischistosomal leads. Current Opinion in Pharmacology, 42. pp. 27-33.

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Official URL: https://edoc.unibas.ch/65206/

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Abstract

The commitment to eliminate schistosomiasis as a public health problem has mobilized the expansion of praziquantel treatment to meet the London Declaration targets. New research has thus sought to elucidate praziquantel's safety and efficacy in key demographics such as preschoolers and pregnant women, as well as novel elements of its pharmacokinetics and pharmacodynamics. At the same time, reliance on praziquantel ad infinitum would place schistosomiasis control at risk, should resistance occur. In response, the academic community has been filling the pre-clinical drug discovery pipeline with novel or resurrected drug candidates against schistosomiasis. In this review, we highlight the latest research on praziquantel treatment dynamics, which aims to improve the utility of this important drug. Moreover, we present the most promising preclinical antischistosomal candidates, which should be studied further to achieve the ultimate goal- an alternative antischistosomal drug in the near future.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Panic, Gordana and Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Review Article
Publisher:Elsevier
ISSN:1471-4892
e-ISSN:1471-4973
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:11 Sep 2018 12:25
Deposited On:11 Sep 2018 12:25

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