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Assessing strategies against gambiense sleeping sickness through mathematical modeling

Rock, Kat S. and Ndeffo-Mbah, Martial L. and Castaño, Soledad and Palmer, Cody and Pandey, Abhishek and Atkins, Katherine E. and Ndung'u, Joseph M. and Hollingsworth, T. Déirdre and Galvani, Alison and Bever, Caitlin and Chitnis, Nakul and Keeling, Matt J.. (2018) Assessing strategies against gambiense sleeping sickness through mathematical modeling. Clinical Infectious Diseases, 66 (Suppl 4). S286-S292.

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Abstract

Control of gambiense sleeping sickness relies predominantly on passive and active screening of people, followed by treatment.; Mathematical modeling explores the potential of 3 complementary interventions in high- and low-transmission settings.; Intervention strategies that included vector control are predicted to halt transmission most quickly. Targeted active screening, with better and more focused coverage, and enhanced passive surveillance, with improved access to diagnosis and treatment, are both estimated to avert many new infections but, when used alone, are unlikely to halt transmission before 2030 in high-risk settings.; There was general model consensus in the ranking of the 3 complementary interventions studied, although with discrepancies between the quantitative predictions due to differing epidemiological assumptions within the models. While these predictions provide generic insights into improving control, the most effective strategy in any situation depends on the specific epidemiology in the region and the associated costs.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Infectious Disease Modelling (Smith)
UniBasel Contributors:Chitnis, Nakul
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:1058-4838
e-ISSN:1537-6591
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:07 Sep 2018 14:04
Deposited On:03 Jul 2018 09:04

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