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Is there an association between ambient air pollution and bladder cancer incidence? Analysis of 15 European cohorts

Pedersen, Marie and Stafoggia, Massimo and Weinmayr, Gudrun and Andersen, Zorana J. and Galassi, Claudia and Sommar, Johan and Forsberg, Bertil and Olsson, David and Oftedal, Bente and Krog, Norun H. and Aamodt, Geir and Pyko, Andrei and Pershagen, Göran and Korek, Michal and De Faire, Ulf and Pedersen, Nancy L. and Östenson, Claes-Göran and Fratiglioni, Laura and Sørensen, Mette and Eriksen, Kirsten T. and Tjønneland, Anne and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Vermeulen, Roel and Eeftens, Marloes and Plusquin, Michelle and Key, Timothy J. and Jaensch, Andrea and Nagel, Gabriele and Concin, Hans and Wang, Meng and Tsai, Ming-Yi and Grioni, Sara and Marcon, Alessandro and Krogh, Vittorio and Ricceri, Fulvio and Sacerdote, Carlotta and Ranzi, Andrea and Cesaroni, Giulia and Forastiere, Francesco and Tamayo, Ibon and Amiano, Pilar and Dorronsoro, Miren and Stayner, Leslie T. and Kogevinas, Manolis and Nieuwenhuijsen, Mark J. and Sokhi, Ranjeet and de Hoogh, Kees and Beelen, Rob and Vineis, Paolo and Brunekreef, Bert and Hoek, Gerard and Raaschou-Nielsen, Ole. (2018) Is there an association between ambient air pollution and bladder cancer incidence? Analysis of 15 European cohorts. European urology focus, 4 (1). pp. 113-120.

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Official URL: https://edoc.unibas.ch/64880/

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Abstract

Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.; To evaluate the association between long-term exposure to ambient air pollution and BC incidence.; We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO; 2; and NO; x; ), particulate matter (PM) with diameter <10μm (PM; 10; ), <2.5μm (PM; 2.5; ), between 2.5 and 10μm (PM; 2.5-10; ), PM; 2.5; absorbance; (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.; We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.; During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-μg/m; 3; increase in NO; 2; and 5-μg/m; 3; increase in PM; 2.5; were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure.; There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.; We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Eeftens, Marloes and Tsai, Ming-Yi and de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2405-4569
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Jul 2018 11:23
Deposited On:03 Jul 2018 11:23

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