Unique human immune signature of Ebola virus disease in Guinea

Ruibal, Paula and Oestereich, Lisa and Lüdtke, Anja and Becker-Ziaja, Beate and Wozniak, David M. and Kerber, Romy and Korva, Miša and Cabeza-Cabrerizo, Mar and Bore, Joseph A. and Koundouno, Fara Raymond and Duraffour, Sophie and Weller, Romy and Thorenz, Anja and Cimini, Eleonora and Viola, Domenico and Agrati, Chiara and Repits, Johanna and Afrough, Babak and Cowley, Lauren A. and Ngabo, Didier and Hinzmann, Julia and Mertens, Marc and Vitoriano, Inês and Logue, Christopher H. and Boettcher, Jan Peter and Pallasch, Elisa and Sachse, Andreas and Bah, Amadou and Nitzsche, Katja and Kuisma, Eeva and Michel, Janine and Holm, Tobias and Zekeng, Elsa-Gayle and García-Dorival, Isabel and Wölfel, Roman and Stoecker, Kilian and Fleischmann, Erna and Strecker, Thomas and Di Caro, Antonino and Avšič-Županc, Tatjana and Kurth, Andreas and Meschi, Silvia and Mély, Stephane and Newman, Edmund and Bocquin, Anne and Kis, Zoltan and Kelterbaum, Anne and Molkenthin, Peter and Carletti, Fabrizio and Portmann, Jasmine and Wolff, Svenja and Castilletti, Concetta and Schudt, Gordian and Fizet, Alexandra and Ottowell, Lisa J. and Herker, Eva and Jacobs, Thomas and Kretschmer, Birte and Severi, Ettore and Ouedraogo, Nobila and Lago, Mar and Negredo, Anabel and Franco, Leticia and Anda, Pedro and Schmiedel, Stefan and Kreuels, Benno and Wichmann, Dominic and Addo, Marylyn M. and Lohse, Ansgar W. and De Clerck, Hilde and Nanclares, Carolina and Jonckheere, Sylvie and Van Herp, Michel and Sprecher, Armand and Xiaojiang, Gao and Carrington, Mary and Miranda, Osvaldo and Castro, Carlos M. and Gabriel, Martin and Drury, Patrick and Formenty, Pierre and Diallo, Boubacar and Koivogui, Lamine and Magassouba, N'Faly and Carroll, Miles W. and Günther, Stephan and Muñoz-Fontela, César. (2016) Unique human immune signature of Ebola virus disease in Guinea. Nature, 533 (7601). pp. 100-104.

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Official URL: https://edoc.unibas.ch/64783/

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Abstract

Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of EVD. In particular, very little is known about human immune responses to Ebola virus. Here we evaluate the physiology of the human T cell immune response in EVD patients at the time of admission to the Ebola Treatment Center in Guinea, and longitudinally until discharge or death. Through the use of multiparametric flow cytometry established by the European Mobile Laboratory in the field, we identify an immune signature that is unique in EVD fatalities. Fatal EVD was characterized by a high percentage of CD4(+) and CD8(+) T cells expressing the inhibitory molecules CTLA-4 and PD-1, which correlated with elevated inflammatory markers and high virus load. Conversely, surviving individuals showed significantly lower expression of CTLA-4 and PD-1 as well as lower inflammation, despite comparable overall T cell activation. Concomitant with virus clearance, survivors mounted a robust Ebola-virus-specific T cell response. Our findings suggest that dysregulation of the T cell response is a key component of EVD pathophysiology.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:	Bah, Amadou
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Macmillan
ISSN:	0028-0836
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1038/nature17949 pmid: 27147028
Last Modified:	16 Jul 2018 07:16
Deposited On:	16 Jul 2018 07:16

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