Analysis of diagnostic findings from the european mobile laboratory in Gueckedou, Guinea, march 2014 through march 2015

Kerber, Romy and Krumkamp, Ralf and Diallo, Boubacar and Jaeger, Anna and Rudolf, Martin and Lanini, Simone and Bore, Joseph Akoi and Koundouno, Fara Raymond and Becker-Ziaja, Beate and Fleischmann, Erna and Stoecker, Kilian and Meschi, Silvia and Mély, Stéphane and Newman, Edmund N. C. and Carletti, Fabrizio and Portmann, Jasmine and Korva, Misa and Wolff, Svenja and Molkenthin, Peter and Kis, Zoltan and Kelterbaum, Anne and Bocquin, Anne and Strecker, Thomas and Fizet, Alexandra and Castilletti, Concetta and Schudt, Gordian and Ottowell, Lisa and Kurth, Andreas and Atkinson, Barry and Badusche, Marlis and Cannas, Angela and Pallasch, Elisa and Bosworth, Andrew and Yue, Constanze and Pályi, Bernadett and Ellerbrok, Heinz and Kohl, Claudia and Oestereich, Lisa and Logue, Christopher H. and Lüdtke, Anja and Richter, Martin and Ngabo, Didier and Borremans, Benny and Becker, Dirk and Gryseels, Sophie and Abdellati, Saïd and Vermoesen, Tine and Kuisma, Eeva and Kraus, Annette and Liedigk, Britta and Maes, Piet and Thom, Ruth and Duraffour, Sophie and Diederich, Sandra and Hinzmann, Julia and Afrough, Babak and Repits, Johanna and Mertens, Marc and Vitoriano, Inês and Bah, Amadou and Sachse, Andreas and Boettcher, Jan Peter and Wurr, Stephanie and Bockholt, Sabrina and Nitsche, Andreas and Županc, Tatjana Avšič and Strasser, Marc and Ippolito, Giuseppe and Becker, Stephan and Raoul, Herve and Carroll, Miles W. and De Clerck, Hilde and Van Herp, Michel and Sprecher, Armand and Koivogui, Lamine and Magassouba, N'Faly and Keïta, Sakoba and Drury, Patrick and Gurry, Cèline and Formenty, Pierre and May, Jürgen and Gabriel, Martin and Wölfel, Roman and Günther, Stephan and Di Caro, Antonino. (2016) Analysis of diagnostic findings from the european mobile laboratory in Gueckedou, Guinea, march 2014 through march 2015. Journal of infectious diseases, 214 (Suppl 3). pp. 250-S257.

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Official URL: https://edoc.unibas.ch/64780/

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Abstract

A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015.; The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively.; The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome.; Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:	Bah, Amadou
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Oxford University Press
ISSN:	0022-1899
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1093/infdis/jiw269 pmid: 27638946
Last Modified:	04 Jul 2018 12:23
Deposited On:	04 Jul 2018 12:23

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