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Ebola virus disease, Democratic Republic of the Congo, 2014

Nanclares, Carolina and Kapetshi, Jimmy and Lionetto, Fanshen and de la Rosa, Olimpia and Tamfun, Jean-Jacques Muyembe and Alia, Miriam and Kobinger, Gary and Bernasconi, Andrea. (2016) Ebola virus disease, Democratic Republic of the Congo, 2014. Emerging infectious diseases, 22 (9). pp. 1579-1586.

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Official URL: https://edoc.unibas.ch/64775/

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Abstract

During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Swiss Centre for International Health (SCIH) > Health Systems Support (Prytherch)
UniBasel Contributors:Bernasconi, Andrea
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Center for Infectious Diseases
ISSN:1080-6040
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:04 Jul 2018 12:10
Deposited On:04 Jul 2018 12:10

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