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Visuomotor coupling shapes a sensorimotor circuit in mouse Cortex for visual flow predictions

Attinger, Alexander. Visuomotor coupling shapes a sensorimotor circuit in mouse Cortex for visual flow predictions. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_12667

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Abstract

The emergence of sensory guided behavior depends on sensorimotor coupling during development. How sensorimotor experience shapes neural processing is unclear. Here we show that the coupling between motor output and visual feedback is necessary for the functional development of visual processing in layer 2/3 (L2/3) of primary visual cortex (V1) of the mouse. Using a virtual reality system, we reared mice in conditions of normal or random visuomotor coupling. We recorded the activity of identified excitatory and inhibitory L2/3 neurons in response to transient visuomotor mismatches in both groups of mice. Mismatch responses in excitatory neurons were strongly experience dependent and driven by a transient release from inhibition mediated by somatostatin-positive interneurons. These data are consistent with a model in which L2/3 of V1 computes a difference between an inhibitory visual input and an excitatory locomotion-related input, where the balance between these two inputs is finely tuned by visuomotor experience.
Advisors:Keller, Georg and Friedrich, Rainer W.
Faculties and Departments:05 Faculty of Science
09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Sensory processing in the visual cortex (Keller)
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12667
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (88 Seiten)
Language:English
Identification Number:
Last Modified:12 Jul 2018 09:25
Deposited On:12 Jul 2018 09:24

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