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Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults : the EGEA study

Havet, Anaïs and Zerimech, Farid and Sanchez, Margaux and Siroux, Valérie and Le Moual, Nicole and Brunekreef, Bert and Stempfelet, Morgane and Künzli, Nino and Jacquemin, Bénédicte and Matran, Régis and Nadif, Rachel. (2018) Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults : the EGEA study. European Respiratory Journal, 51 (4). p. 1702036.

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Abstract

Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM; 10; and PM; 2.5; ), road traffic, and ozone (O; 3; ) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O; 3; exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m; -3; ) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL; -1; ). Among participants without asthma, exhaled 8-iso concentration increased with PM; 2.5; exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m; -3; ), and decreased with O; 3; and O; 3-summer; exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m; -3; , respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:European Respiratory Society
ISSN:0903-1936
e-ISSN:1399-3003
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:14 Sep 2018 13:45
Deposited On:03 Jul 2018 08:12

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