Aiding Nature's Organelles: Artificial Peroxisomes Play Their Role

Tanner, Pascal and Balasubramanian, Vimalkumar and Palivan, Cornelia G.. (2013) Aiding Nature's Organelles: Artificial Peroxisomes Play Their Role. Nano Letters, 13 (6). pp. 2875-2883.

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Official URL: https://edoc.unibas.ch/63376/

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A major goal in medical research is to develop artificial organelles that can implant in cells to treat pathological conditions or to support the design of artificial cells. Several attempts have been made to encapsulate or entrap enzymes, proteins, or mimics in polymer compartments, but only few of these nanoreactors were active in cells, and none was proven to mimic a specific natural organelle. Here, we show the necessary steps for the development of an artificial organelle mimicking a natural organelle, the peroxisome. The system, based on two enzymes that work in tandem in polymer vesicles, with a membrane rendered permeable by inserted channel proteins was optimized in terms of natural peroxisome properties and function. The uptake, absence of toxicity, and in situ activity in cells exposed to oxidative stress demonstrated that the artificial peroxisomes detoxify superoxide radicals and H2O2 after endosomal escape. Our artificial peroxisome combats oxidative stress in cells, a factor in various pathologies (e.g., arthritis, Parkinsons, cancer, AIDS), and offers a versatile strategy to develop other "cell implants" for cell dysfunction.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Apr 2018 08:33
Deposited On:16 Apr 2018 08:33

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