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The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

Hofmann, Natalie E. and Karl, Stephan and Wampfler, Rahel and Kiniboro, Benson and Teliki, Albina and Iga, Jonah and Waltmann, Andreea and Betuela, Inoni and Felger, Ingrid and Robinson, Leanne J. and Mueller, Ivo. (2017) The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea. eLife, 6. e23708.

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Official URL: https://edoc.unibas.ch/63157/

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Abstract

The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.; ClinicalTrials.gov NCT02143934.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Diagnostics (Felger)
UniBasel Contributors:Hofmann, Natalie and Wampfler, Rahel and Felger, Ingrid
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1534-4983
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Jul 2018 13:29
Deposited On:02 Jul 2018 13:29

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