Fusar-Poli, Paolo and Allen, Paul and Bhattacharyya, Sagnik and Crippa, José A. and Mechelli, Andrea and Borgwardt, Stefan and Martin-Santos, Rocio and Seal, Marc L. and O'Carrol, Colin and Atakan, Zerrin and Zuardi, Antonio W. and McGuire, Philip. (2010) Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The international journal of neuropsychopharmacology, 13 (4). pp. 421-432.
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Official URL: https://edoc.unibas.ch/63126/
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Abstract
Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta 9-tetrahydrocannabinol (Delta 9-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta 9-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.
Faculties and Departments: | 03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt) |
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UniBasel Contributors: | Borgwardt, Stefan |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Oxford University Press |
ISSN: | 1461-1457 |
e-ISSN: | 1469-5111 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 10 Aug 2020 12:14 |
Deposited On: | 10 Aug 2020 12:14 |
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