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Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology

Schmidt, André and Lenz, Claudia and Smieskova, Renata and Harrisberger, Fabienne and Walter, Anna and Riecher-Rössler, Anita and Simon, Andor and Lang, Undine E. and McGuire, Philip and Fusar-Poli, Paolo and Borgwardt, Stefan J.. (2015) Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology. Neuro-Signals, 23 (1). pp. 71-83.

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Abstract

Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk samples and findings in both groups are inconsistent, in particular along the superior longitudinal fasciculus (SLF).; This DTI study used tract-based spatial statistics (TBSS) to compare fractional anisotropy (FA) and mean diffusivity (MD) between ARMS subjects, untreated and antipsychotic-treated FEP patients and healthy controls (HC) across the whole brain and the SLF.; Compared to HC, ARMS and FEP patients showed increased FA and decreased MD in diverse regions across the whole brain including the SLF. FA in the SLF was positively correlated with positive psychotic symptoms in ARMS and FEP individuals. Furthermore, untreated but not treated FEP patients showed increased FA in the left inferior longitudinal fasciculus and right SLF.; This study revealed increased FA and decreased MD in early stages of psychosis in widespread white matter tracts including the SLF. Our findings further suggest that microstructural changes in the SLF are probably related to state-dependent psychopathology.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Harrisberger, Fabienne and Schmidt, André and Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Karger
ISSN:1424-862X
e-ISSN:1424-8638
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:05 Apr 2019 13:59
Deposited On:09 Aug 2018 15:43

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