Orbitofrontal response to drug‐related stimuli after heroin administration

Walter, M. and Denier, N. and Gerber, H. and Schmid, O. and Lanz, C. and Brenneisen, R. and Riecher-Rössler, A. and Wiesbeck, G. A. and Scheffler, K. and Seifritz, E. and McGuire, P. and Fusar-Poli, P. and Borgwardt, S.. (2015) Orbitofrontal response to drug‐related stimuli after heroin administration. Addiction Biology, 20 (3). pp. 570-579.

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Official URL: https://edoc.unibas.ch/62970/

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The compulsion to seek and use heroin is frequently driven by stress and craving during drug-cue exposure. Although previous neuroimaging studies have indicated that craving is mediated by increased prefrontal cortex activity, it remains unknown how heroin administration modulates the prefrontal cortex response. This study examines the acute effects of heroin on brain function in heroin-maintained patients. Using a crossover, double-blind, placebo-controlled design, 27 heroin-maintained patients performed functional magnetic resonance imaging 20 minutes after the administration of heroin or placebo (saline) while drug-related and neutral stimuli were presented. Images were processed and analysed with statistical parametric mapping. Plasma concentrations of heroin and its main metabolites were assessed using high-performance liquid chromatography. Region of interest analyses showed a drug-related cue-associated blood-oxygen-level-dependent activation in the orbitofrontal cortex (OFC) in heroin-dependent patients during both treatment conditions (heroin and placebo). This activation of the OFC was significantly higher after heroin than after placebo administration. These findings may indicate the importance of OFC activity for impulse control and decision-making after regular heroin administration and may emphasize the benefit of the heroin-assisted treatment in heroin dependence.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley-Blackwell - STM
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Aug 2019 13:09
Deposited On:04 Dec 2018 19:57

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