Visualization of prion-like transfer in Huntington's disease models

Jansen, Anne H. and Batenburg, Kevin L. and Pecho-Vrieseling, Eline and Reits, Eric A.. (2017) Visualization of prion-like transfer in Huntington's disease models. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (3). pp. 793-800.

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Most neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's disease are hallmarked by aggregate formation of disease-related proteins. In various of these diseases transfer of aggregation-prone proteins between neurons and between neurons and glial cells has been shown, thereby initiating aggregation in neighboring cells and so propagating the disease phenotype. Whereas this prion-like transfer is well studied in Alzheimer's and Parkinson's disease, only a few studies have addressed this potential mechanism in Huntington's disease. Here, we present an overview of in vitro and in vivo methodologies to study release, intercellular transfer and uptake of aggregation-prone protein fragments in Huntington's disease models.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Neuronal Development and Degeneration (Pecho-Vrieseling)
UniBasel Contributors:Pecho-Vrieseling, Eline
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:16 Apr 2020 13:36
Deposited On:16 Apr 2020 13:36

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