Predictors of objectively measured medication nonadherence in adults with heart failure

Riegel, Barbara and Lee, Christopher S. and Ratcliffe, Sarah J. and De Geest, Sabina and Potashnik, Sheryl and Patey, Megan and Sayers, Steven L. and Goldberg, Lee R. and Weintraub, William S.. (2012) Predictors of objectively measured medication nonadherence in adults with heart failure. Circulation. Heart failure, 5 (4). pp. 430-436.

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Official URL: https://edoc.unibas.ch/62346/

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Medication nonadherence rates are high. The factors predicting nonadherence in heart failure remain unclear.; A sample of 202 adults with heart failure was enrolled from the northeastern United States and followed for 6 months. Specific aims were to describe the types of objectively measured medication adherence (eg, taking, timing, dosing, drug holidays) and to identify contributors to nonadherence 6 months after enrollment. Latent growth mixture modeling was used to identify distinct trajectories of adherence. Indicators of the 5 World Health Organization dimensions of adherence (socioeconomic, condition, therapy, patient, and healthcare system) were tested to identify contributors to nonadherence. Two distinct trajectories were identified and labeled persistent adherence (77.8%) and steep decline (22.3%). Three contributors to the steep decline in adherence were identified. Participants with lapses in attention (adjusted OR, 2.65; P=0.023), those with excessive daytime sleepiness (OR, 2.51; P=0.037), and those with ≥2 medication dosings per day (OR, 2.59; P=0.016) were more likely to have a steep decline in adherence over time than to have persistent adherence.; Two distinct patterns of adherence were identified. Three potentially modifiable contributors to nonadherence have been identified.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
UniBasel Contributors:De Geest, Sabina M.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Aug 2020 12:21
Deposited On:03 Aug 2020 12:21

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