Scherrer, A. U. and Yang, W. L. and Kouyos, R. D. and Boni, J. and Yerly, S. and Klimkait, T. and Aubert, V. and Cavassini, M. and Battegay, M. and Hauser, C. and Calmy, A. and Schmid, P. and Bernasconi, E. and Gunthard, H. F. and Swiss, H. I. V. Cohort Study. (2016) Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. J Infect Dis, 214 (3). pp. 399-402.
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Official URL: https://edoc.unibas.ch/62179/
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Abstract
The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait) |
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| UniBasel Contributors: | Klimkait, Thomas |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1537-6613 (Electronic) 0022-1899 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 26 May 2020 09:41 |
| Deposited On: | 26 May 2020 09:41 |
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