Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

Keck, Simone and Schmaler, Mathias and Ganter, Stefan and Wyss, Lena and Oberle, Susanne G. and Huseby, Eric S. and Zehn, Dietmar and King, Carolyn G.. (2014) Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 111 (41). pp. 14852-14857.

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Official URL: https://edoc.unibas.ch/62178/

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Cumulative T-cell receptor signal strength and ensuing T-cell responses are affected by both antigen affinity and antigen dose. Here we examined the distinct contributions of these parameters to CD4 T-cell differentiation during infection. We found that high antigen affinity positively correlates with T helper (Th)1 differentiation at both high and low doses of antigen. In contrast, follicular helper T cell (TFH) effectors are generated after priming with high, intermediate, and low affinity ligand. Unexpectedly, memory T cells generated after priming with very low affinity antigen remain impaired in their ability to generate secondary Th1 effectors, despite being recalled with high affinity antigen. These data challenge the view that only strongly stimulated CD4 T cells are capable of differentiating into the TFH and memory T-cell compartments and reveal that differential strength of stimulation during primary T-cell activation imprints unique and long lasting T-cell differentiation programs.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Cell Biology (King)
UniBasel Contributors:King, Carolyn
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Jul 2020 15:28
Deposited On:28 Jul 2020 15:28

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