Affinity for self antigen selects Treg cells with distinct functional properties

Wyss, L. and Stadinski, B. D. and King, C. G. and Schallenberg, S. and McCarthy, N. I. and Lee, J. Y. and Kretschmer, K. and Terracciano, L. M. and Anderson, G. and Surh, C. D. and Huseby, E. S. and Palmer, E.. (2016) Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol, 17 (9). pp. 1093-1101.

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Official URL: https://edoc.unibas.ch/62176/

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The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and controlled lympho-proliferation in peripheral lymph nodes. GITR(lo)PD-1(lo)CD25(lo) (Triple(lo)) Treg cells were less self-reactive and limited the development of colitis by promoting the conversion of CD4(+) Tconv cells into induced Treg cells (iTreg cells). Although Foxp3-deficient (Scurfy) mice lacked Treg cells, they contained Triple(hi)-like and Triple(lo)-like CD4(+) T cells zsuper< T cells infiltrated the skin, whereas Scurfy Triple(lo)CD4(+) T cells induced colitis and wasting disease. These findings indicate that the affinity of the T cell antigen receptor for self antigen drives the differentiation of Treg cells into distinct subsets with non-overlapping regulatory activities.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Cell Biology (King)
UniBasel Contributors:King, Carolyn
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1529-2916 (Electronic) 1529-2908 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 May 2020 17:19
Deposited On:31 May 2020 17:19

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