Impaired antibody response causes persistence of prototypic T cell-contained virus

Bergthaler, Andreas and Flatz, Lukas and Verschoor, Admar and Hegazy, Ahmed N. and Holdener, Martin and Fink, Katja and Eschli, Bruno and Merkler, Doron and Sommerstein, Rami and Horvath, Edit and Fernandez, Marylise and Fitsche, André and Senn, Beatrice M. and Verbeek, J. Sjef and Odermatt, Bernhard and Siegrist, Claire-Anne and Pinschewer, Daniel D.. (2009) Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biology, 7 (4). e1000080.

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Official URL: https://edoc.unibas.ch/61998/

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CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor gamma chain or Fc gamma receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Experimental Virology (Pinschewer)
UniBasel Contributors:Pinschewer, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Dec 2020 13:07
Deposited On:15 Dec 2020 13:07

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