The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses

Bonilla, Weldy V. and Fröhlich, Anja and Senn, Karin and Kallert, Sandra and Fernandez, Marylise and Johnson, Susan and Kreutzfeldt, Mario and Hegazy, Ahmed N. and Schrick, Christina and Fallon, Padraic G. and Klemenz, Roman and Nakae, Susumu and Adler, Heiko and Merkler, Doron and Löhning, Max and Pinschewer, Daniel D.. (2012) The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses. Science, 335 (6071). pp. 984-989.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61986/

Downloads: Statistics Overview


Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Experimental Virology (Pinschewer)
UniBasel Contributors:Pinschewer, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:15 Dec 2020 12:49
Deposited On:15 Dec 2020 12:49

Repository Staff Only: item control page