MicroRNA regulation of T-cell differentiation and function

Jeker, Lukas T. and Bluestone, Jeffrey A.. (2013) MicroRNA regulation of T-cell differentiation and function. Immunological Reviews, 253 (1). pp. 65-81.

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Official URL: https://edoc.unibas.ch/61965/

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MicroRNAs (miRNAs) are emerging as key controllers of T-cell differentiation and function. Their expression is dynamically regulated by extracellular signals such as costimulation and cytokine signals. miRNAs set thresholds for gene expression and optimize protein concentrations of genetic networks. Absence of individual miRNAs can lead to severe immune dysfunction. In this study, we review emerging principles and provide examples of important functions exerted by miRNAs. Although our understanding of miRNA function in T-cell differentiation is still rudimentary, the available evidence leaves no doubt that these small post-transcriptional regulators are indispensable for proper functioning of the immune system.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Molecular Immune Regulation (Jeker)
UniBasel Contributors:Jeker, Lukas T.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley-Blackwell Publishing
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Dec 2020 08:00
Deposited On:16 Dec 2020 08:00

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